Publications

42. Learning induces activation-mechanism—dependent neural plasticity in an intracortical microstimulation task

Robin Kim, Roy Lycke, Pavlo Zolotavin, Jon Montes, Chong Xie, Lan Luan

Accepted to Science Advances

https://doi.org/10.64898/2026.06.05.730421

41. High-channel-count neural recording and stimulation platform with 5,376 simultaneous recording channels Copy

Yingying Fan, Yuhang Ma, Pavlo Zolotavin, Gerald Topalli, Weinan Wang, Mattias Karlsson, Magnus Karlsson, Lan Luan, Chong Xie, Taiyun Chi

Accepted to npj Biomedical Innovations

https://doi.org/10.64898/2026.03.13.709972

40. Fully 3D-printed endomicroscopic objective for two-photon, multi-wavelength excitation microscopy

Jinyun Liu, Roy Lycke, Lan Luan, Tomasz S Tkaczyk

Biomedical Optics Express 17 (1), 82-97

https://doi.org/10.1364/BOE.579476

39. Hybrid endomicroscopic objective with monolithic multi-material achromatic triplet fabricated using two-photon lithography Copy

Jinyun Liu, Roy Lycke, Lan Luan, Tomasz S Tkaczyk

Applied Optics 65 (1), 112-120

https://doi.org/10.1364/AO.579479

38. Temporal coding carries more stable cortical visual representations than firing rate over time Copy Copy

Hanlin Zhu, Fei He, Pavlo Zolotavin, Saumil Patel, Andreas S Tolias, Lan Luan, Chong Xie

Nature Communications 16 (1), 7162

https://doi.org/10.1038/s41467-025-62069-2

37. Towards precise synthetic neural codes: high-dimensional stimulation with flexible electrodes

Robin Kim, Yuxuan Liu, Jiaao Zhang, Chong Xie, Lan Luan

npj Flexible Electronics 9 (1), 68

https://doi.org/10.1038/s41528-025-00447-y

36. Longitudinal, Multimodal Tracking Reveals Lasting Neurovascular Impact of Individual Microinfarcts

Yifu Jin, Fei He, Haad Rathore, Yingchu Sun, Jia-Ao Zhang, Xinyu Li, Rongkang Yin, Hanlin Zhu, Chong Xie, Lan Luan

Advanced science (Weinheim, Baden-Wurttemberg, Germany), e2417003

https://doi.org/10.1002/advs.202417003

35. Ultraflexible electrodes for recording neural activity in the mouse spinal cord during motor behavior

Yu Wu, Benjamin A Temple, Nicole Sevilla, Jiaao Zhang, Hanlin Zhu, Pavlo Zolotavin, Yifu Jin, Daniela Duarte, Elischa Sanders, Eiman Azim, Axel Nimmerjahn, Samuel L Pfaff, Lan Luan, Chong Xie

Cell Reports 43 (5)

https://doi.org/10.1016/j.celrep.2024.114199

34. A 24V Mini-Coil Magnetic Neural Stimulator with Closed-Loop Deadtime Control and ZCS Control Achieving 99.76% Charge Recovery Efficiency

Yingying Fan, Yuxuan Liu, Gerald Topalli, Roy Lycke, Lan Luan, Chong Xie, Taiyun Chi

2024 IEEE International Solid-State Circuits Conference (ISSCC) 67, 322-324

http://10.1109/ISSCC49657.2024.10454319

33. Clinical outcomes of peripheral nerve interfaces for rehabilitation in paralysis and amputation: a literature review

Khaled M Taghlabi, Jesus G Cruz-Garza, Taimur Hassan, Ojas Potnis, Lokeshwar S Bhenderu, Jaime R Guerrero, Rachael E Whitehead, Yu Wu, Lan Luan, Chong Xie, Jacob T Robinson, Amir H Faraji

Journal of Neural Engineering

https://doi.org/10.1088/1741-2552/ad200f

32. A Complementary Pseudo-Resistor with Leakage Current Self-Compensation for Biopotential Amplifiers Copy

Gerald Topalli, Chong Xie, Yingying Fan, Lan Luan, Rongkang Yin, Taiyun Chi

2023 IEEE Biomedical Circuits and Systems Conference (BioCAS), 1-4

https://doi.org/10.1109/BioCAS58349.2023.10389136

31. Low-threshold, high-resolution, chronically stable intracortical microstimulation by ultraflexible electrodes Copy

Roy Lycke, Robin Kim, Pavlo Zolotavin, Jon Montes, Yingchu Sun, Aron Koszeghy, Esra Altun, Brian Noble, Rongkang Yin, Fei He, Nelson Totah, Chong Xie, Lan Luan

Cell Reports 42 (6)

https://doi.org/10.1016/j.celrep.2023.112554

30. Emerging Penetrating Neural Electrodes: In Pursuit of Large Scale and Longevity

Lan Luan, Rongkang Yin, Hanlin Zhu, and Chong Xie

Annual Review of Biomedical Engineering 25, 185-205

https://doi.org/10.1146/annurev-bioeng-090622-050507

29. Longitudinal neural and vascular recovery following ultraflexible neural electrode implantation in aged mice

Fei He, Yingchu Sun, Yifu Jin, Rongkang Yin, Hanlin Zhu, Haad Rathore, Chong Xie and Lan Luan

Biomaterials, 121905

https://doi.org/10.1016/j.biomaterials.2022.121905

28. Ultraflexible electrode arrays for months-long high-density electrophysiological mapping of thousands of neurons in rodents

Zhengtuo Zhao, Hanlin Zhu, Xue Li, Liuyang Sun, Fei He, Jason E. Chung, Daniel F. Liu, Loren Frank, Lan Luan, and Chong Xie

Nature Biomedical Engineering, 2023

https://doi.org/10.1038/s41551-022-00941-y

27. Chronic co-implantation of ultraflexible neural electrodes and a cranial window

Rongkang Yin, Brian C. Noble, Fei He, Pavlo Zolotavin, Haad Rathore, Yifu Jin, Nicole Sevilla, Chong Xie, Lan Luan

Neurophotonics, 9, 032204 (2022)

https://doi.org/10.1117/1.NPh.9.3.032204

26. Dynamics of isoflurane-induced vasodilation and blood flow of cerebral vasculature revealed by multi-exposure speckle imaging

Colin T.Sullendera, Lisa M.Richards, Fei He, Lan Luan, Andrew K.Dunn

Journal of Neuroscience Methods, 366, 109434 (2021)

https://doi.org/10.1016/j.jneumeth.2021.109434

25. Optimized design of a hyperflexible sieve electrode to enhance neurovascular regeneration for a peripheral neural interface

Austin Veitha, Xue Li, Hailey Modia, Ali Abbaspoura, Lan Luan, Chong Xie, Aaron B.Baker

Biomaterials, 275, 120924 (2021)

https://doi.org/10.1016/j.biomaterials.2021.120924

24: Recent Advances in Electrical Neural Interface Engineering: Minimal Invasiveness, Longevity, and Scalability

Lan Luan, Jacob T.Robinson, Behnaam Aazhang, Taiyun Chi, KaiyuanYang, Xue Li, Haad Rathore, Amanda Singer, Sudha Yellapantula, Yingying Fan, Zhanghao Yu, and ChongXie

Neuron 108, 302 (2020)

https://doi.org/10.1016/j.neuron.2020.10.011

23. Ultraflexible neural electrodes for long-lasting intracortical recording

Fei He, Roy Lycke, Mehran Ganji, Chong Xie, Lan Luan

iScience, 23, 101387 (2020).

https://doi.org/10.1016/j.isci.2020.101387

22. Multimodal mapping of neural activity and cerebral blood flow reveals long-lasting neurovascular dissociations after small-scale strokes

Fei He, Colin T Sullender, Hanlin Zhu, Michael R Williamson, Xue Li, Zhengtuo Zhao, Theresa A Jones, Chong Xie, Andrew K Dunn, Lan Luan

Science Advances, 6, eaba1933 (2020)

https://doi.org/10.1126/sciadv.aba1933

21. Spikes to Pixels: Camera Chips for Large-scale Electrophysiology

Roy Lycke, Liuyang Sun, Lan Luan, and Chong Xie

Trends in Neurosciences, Vol. 43, No. 5, 269 (2020)

https://doi.org/10.1016/j.tins.2020.03.001

20. Can One Concurrently Record Electrical Spikes from Every Neuron in a Mammalian Brain?

David Kleinfeld, Lan Luan, Partha P. Mitra, Jacob T. Robinson, Rahul Sarpeshkar, Kenneth Shepard, Chong Xie, Timothy D. Harris

Neuron 103, 1 (2019)

https://doi.org/10.1016/j.neuron.2019.08.011

19. Nanoelectronics enabled chronic multimodal neural platform in a mouse ischemic model

Lan Luan, Colin T Sullender, Xue Li, Zhengtuo Zhao, Hanlin Zhu, Xiaoling Wei, Chong Xie, Andrew K Dunn

Journal of Neuroscience Methods, 295, 68 (2018)

https://doi.org/10.1016/j.jneumeth.2017.12.001

Rice University, Department of Electrical and Computer Engineering Department of Bioengineering